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The effects of lansoprazole (LP) on plasma gastrin and gastric acid secretion were investigated in conscious fasted dogs. LP (30 mg/kg i.v.) significantly increased the plasma gastrin concentrations 1, 2 and 3 h after injection. The plasma gastrin response to LP was enhanced in dogs in which an antral gastrin-containing cell was removed by acid pretreatment of the stomach with 3 M HCl. Similar increases in plasma gastrin concentrations were seen when LP was given to animals with gastrin-releasing peptide (GRP) receptors in the stomach, as well as in animals pretreated with GRP, or in animals treated with atropine, i.v. The LP-induced increases in plasma gastrin concentrations were not observed in animals pretreated with the cholinergic receptor antagonist, atropine, given 10 min before LP. Atropine alone had no significant effect on plasma gastrin concentrations. LP at 30 mg/kg i.v. significantly increased basal and pentagastrin-stimulated acid output but only at 3 h post-injection. It is concluded that LP stimulates gastrin secretion in the dog by enhancing gastrin release from the antral gastrin-containing cell. The LP-induced increase in plasma gastrin concentrations was not due to an increase in the secretory response of the gastric acid-secreting cells.More than half of the modern-day horse breeds in the world are being affected by inbreeding, research has shown.
The genetic diversity of many of the 350 horse breeds in existence today has been lost because of humans reducing the amount of gene flow between different breeds and breeds and breed lines “inbreeding”.
Researchers from the University of Kentucky have pinpointed the most popular breeds for this genetic problem and used that information to develop a model which allowed them to predict the effect of every modern breed in the world.
“Breed diversity is essential for healthy populations,” explained Dr Carol Baker from the University of Kentucky’s Animal Breeding and Genomics Lab.
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